Review

. 2018 Nov;5(11):e656-e666.

doi: 10.1016/S2352-3018(18)30134-6. Epub 2018 Aug 30.

Ethical considerations in global HIV phylogenetic research

Cordelia E M Coltart¹, Anne Hoppe², Michael Parker³, Liza Dawson⁴, Joseph J Amon⁵, Musonda Simwinga⁶, Gail Geller⁷, Gail Henderson⁸, Oliver Laeyendecker⁹, Joseph D Tucker¹⁰, Patrick Eba¹¹, Vladimir Novitsky¹², Anne-Mieke Vandamme¹³, Janet Seeley¹⁴, Gina Dallabetta¹⁵, Guy Harling¹⁶, M Kate Grabowski¹⁷, Peter Godfrey-Faussett¹⁸, Christophe Fraser¹⁹, Myron S Cohen²⁰, Deenan Pillay²¹; Ethics in HIV Phylogenetics Working Group

Collaborators, Affiliations

Collaborators

Affiliations

¹ Institute for Global Health, University College London, London, UK.
² Division of Infection and Immunity, University College London, London, UK. Electronic address: a.hoppe@ucl.ac.uk.
³ The Wellcome Centre for Ethics and Humanities (Ethox), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
⁴ Division of AIDS, National Institutes of Health, Bethesda, MD, USA.
⁵ Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ, USA.
⁶ Zambart, University of Zambia, Lusaka, Zambia.
⁷ Berman Institute of Bioethics and School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁸ Center for Genomics and Society, Department of Social Medicine, University of North Carolina, Chapel Hill, NC, USA.
⁹ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
¹⁰ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
¹¹ Community Support, Social Justice and Inclusion Department, Geneva, Switzerland; School of Law, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
¹² Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
¹³ Clinical and Epidemiological Virology, Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven, Belgium; Center for Global Health and Tropical Medicine, Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
¹⁴ Africa Health Research Institute, KwaZulu-Natal, South Africa; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK.
¹⁵ Bill & Melinda Gates Foundation, Washington, DC, USA.
¹⁶ Institute for Global Health, University College London, London, UK; Africa Health Research Institute, KwaZulu-Natal, South Africa.
¹⁷ Department of Pathology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Rakai Community Cohort Study, Rakai Health Sciences Program, Kalisizo, Uganda.
¹⁸ Joint United Nations Programme on HIV/AIDS, Geneva, Switzerland; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
¹⁹ Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
²⁰ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
²¹ Division of Infection and Immunity, University College London, London, UK; Africa Health Research Institute, KwaZulu-Natal, South Africa.

PMID: 30174214
PMCID: PMC7327184
DOI: 10.1016/S2352-3018(18)30134-6

Review

Ethical considerations in global HIV phylogenetic research

Cordelia E M Coltart et al. Lancet HIV. 2018 Nov.

. 2018 Nov;5(11):e656-e666.

doi: 10.1016/S2352-3018(18)30134-6. Epub 2018 Aug 30.

Authors

Collaborators

Affiliations

¹ Institute for Global Health, University College London, London, UK.
² Division of Infection and Immunity, University College London, London, UK. Electronic address: a.hoppe@ucl.ac.uk.
³ The Wellcome Centre for Ethics and Humanities (Ethox), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
⁴ Division of AIDS, National Institutes of Health, Bethesda, MD, USA.
⁵ Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ, USA.
⁶ Zambart, University of Zambia, Lusaka, Zambia.
⁷ Berman Institute of Bioethics and School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁸ Center for Genomics and Society, Department of Social Medicine, University of North Carolina, Chapel Hill, NC, USA.
⁹ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
¹⁰ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
¹¹ Community Support, Social Justice and Inclusion Department, Geneva, Switzerland; School of Law, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
¹² Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
¹³ Clinical and Epidemiological Virology, Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven, Belgium; Center for Global Health and Tropical Medicine, Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
¹⁴ Africa Health Research Institute, KwaZulu-Natal, South Africa; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK.
¹⁵ Bill & Melinda Gates Foundation, Washington, DC, USA.
¹⁶ Institute for Global Health, University College London, London, UK; Africa Health Research Institute, KwaZulu-Natal, South Africa.
¹⁷ Department of Pathology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Rakai Community Cohort Study, Rakai Health Sciences Program, Kalisizo, Uganda.
¹⁸ Joint United Nations Programme on HIV/AIDS, Geneva, Switzerland; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
¹⁹ Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
²⁰ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
²¹ Division of Infection and Immunity, University College London, London, UK; Africa Health Research Institute, KwaZulu-Natal, South Africa.

PMID: 30174214
PMCID: PMC7327184
DOI: 10.1016/S2352-3018(18)30134-6

Abstract

Phylogenetic analysis of pathogens is an increasingly powerful way to reduce the spread of epidemics, including HIV. As a result, phylogenetic approaches are becoming embedded in public health and research programmes, as well as outbreak responses, presenting unique ethical, legal, and social issues that are not adequately addressed by existing bioethics literature. We formed a multidisciplinary working group to explore the ethical issues arising from the design of, conduct in, and use of results from HIV phylogenetic studies, and to propose recommendations to minimise the associated risks to both individuals and groups. We identified eight key ethical domains, within which we highlighted factors that make HIV phylogenetic research unique. In this Review, we endeavoured to provide a framework to assist researchers, public health practitioners, and funding institutions to ensure that HIV phylogenetic studies are designed, done, and disseminated in an ethical manner. Our conclusions also have broader relevance for pathogen phylogenetics.

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Figures

**Figure 1:. Applications of phylogenetic analyses**
*Denotes a potential future use of phylogenetic analyses

**Figure 2:**
Potential benefits (left) and harms (right) associated with HIV phylogenetic analysis

See this image and copyright information in PMC

References

1. UNAIDS. AIDS by numbers 2015. Geneva: UNAIDS, 2015.
1. Dennis AM, Herbeck JT, Leigh Brown A, Kellam P, de Oliveira T, Pillay D, et al. Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where the burden is greatest? J Acquir Immune Defic Syndr. 2014;67(2):181–95. - PMC - PubMed
1. Grabowski MK, Lessler J, Redd AD, Kagaayi J, Laeyendecker O, Ndyanabo A, et al. The role of viral introductions in sustaining community-based HIV epidemics in rural Uganda: evidence from spatial clustering, phylogenetics, and egocentric transmission models. PLoS Med. 2014;11(3):e1001610. - PMC - PubMed
1. De Oliveira T, Kharsany AB, Graf T, Cawood C, Khanyile D, Grobler A, et al. Transmission networks and risk of HIV infection in KwaZulu-Natal, South Africa: a community-wide phylogenetic study. Lancet HIV. 2017;4(1):e41–e50. - PMC - PubMed
1. Pillay D, Herbeck JT, Cohen MS, de Oliveira T, Fraser C, Leigh Brown A, et al. PANGEA-HIV: phylogenetics for generalised epidemics in Africa. Lancet Infect Dis. 2015; 15(3):259–61. - PMC - PubMed

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Ethical considerations in global HIV phylogenetic research

Collaborators

Affiliations

Ethical considerations in global HIV phylogenetic research

Authors

Collaborators

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials