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. 1986 Jul;5(7):1529-33.
doi: 10.1002/j.1460-2075.1986.tb04393.x.

Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene

P Martin, C Henry, F Ferre, M Duterque-Coquillaud, C Lagrou, J Ghysdael, B Debuire, D Stehelin, S Saule

Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene

P Martin et al. EMBO J. 1986 Jul.

Abstract

We have constructed avian retroviruses expressing the human c-myc oncogene. These viruses morphologically transformed primary quail embryo fibroblasts upon transfection and infection. Transformed cells produced viruses harboring a spliced c-myc gene and contained high levels of p64-67c-myc protein. One of these infectious viruses, vSX-AHM, was molecularly cloned and the nucleotide sequence of the spliced c-myc insert determined. No mutation was found within the c-myc coding sequence of this transforming clone when compared to the normal genomic progenitor. Thus, we concluded that no mutation within the human c-myc gene is required to induce primary avian embryo fibroblast transformation.

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References

    1. Proc Natl Acad Sci U S A. 1985 Feb;82(3):879-82 - PubMed
    1. Nature. 1985 Nov 21-27;318(6043):237 - PubMed
    1. J Virol. 1981 Aug;39(2):625-31 - PubMed
    1. Nature. 1983 Dec 22-1984 Jan 4;306(5945):760-5 - PubMed
    1. Cell. 1983 Oct;34(3):779-87 - PubMed

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