The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

K Murtoniemi¹, T Vahlberg², E Hämäläinen³, E Kajantie⁴, A K Pesonen⁵, K Räikkönen⁶, P Taipale⁷, P M Villa⁸, H Laivuori⁹

Affiliations

¹ Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, P.O. Box 63, FI-00014 University of Helsinki, Finland; Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, PO Box 52, FI-20521 Turku, Finland. Electronic address: katja.murtoniemi@helsinki.fi.
² Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, FI-20014 University of Turku, Finland. Electronic address: tervah@utu.fi.
³ Vita Healthcare Service Ltd., Laivakatu 5 F, FI-00150 Helsinki, Finland; Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland. Electronic address: esa.hamalainen@vita.fi.
⁴ National Institute for Health and Welfare, Chronic Disease Prevention Unit, FI-00271 Helsinki, Finland; Hospital for Children and Adolescents, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, FI-00029 HUS, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland. Electronic address: eero.kajantie@helsinki.fi.
⁵ Department of Psychology and Logopedics, University of Helsinki, Faculty of Medicine, P.O.Box 63, FI-00014 University of Helsinki, Finland. Electronic address: anukatriina.pesonen@helsinki.fi.
⁶ Department of Psychology and Logopedics, University of Helsinki, Faculty of Medicine, P.O.Box 63, FI-00014 University of Helsinki, Finland. Electronic address: katri.raikkonen@helsinki.fi.
⁷ Terveystalo Oy, Asemakatu 22-24, FI-70100 Kuopio, Finland. Electronic address: pekka.taipale@terveystalo.com.
⁸ Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Haartmaninkatu 2, P.O. Box 140, FI-00029 HUS, Finland. Electronic address: pia.villa@helsinki.fi.
⁹ Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, P.O. Box 63, FI-00014 University of Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, P.O.Box 20, FI-00014 University of Helsinki, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital, PO Box 2000, FI-33521 Tampere, Finland; Faculty of Medicine and Life Sciences, P.O. Box 100, FI-33014 University of Tampere, Finland. Electronic address: hannele.laivuori@staff.uta.fi.

PMID: 30177071
DOI: 10.1016/j.preghy.2018.04.003

Clinical Trial

The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

K Murtoniemi et al. Pregnancy Hypertens. 2018 Jul.

. 2018 Jul:13:51-57.

doi: 10.1016/j.preghy.2018.04.003. Epub 2018 Apr 7.

Authors

K Murtoniemi¹, T Vahlberg², E Hämäläinen³, E Kajantie⁴, A K Pesonen⁵, K Räikkönen⁶, P Taipale⁷, P M Villa⁸, H Laivuori⁹

Affiliations

¹ Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, P.O. Box 63, FI-00014 University of Helsinki, Finland; Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, PO Box 52, FI-20521 Turku, Finland. Electronic address: katja.murtoniemi@helsinki.fi.
² Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, FI-20014 University of Turku, Finland. Electronic address: tervah@utu.fi.
³ Vita Healthcare Service Ltd., Laivakatu 5 F, FI-00150 Helsinki, Finland; Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland. Electronic address: esa.hamalainen@vita.fi.
⁴ National Institute for Health and Welfare, Chronic Disease Prevention Unit, FI-00271 Helsinki, Finland; Hospital for Children and Adolescents, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, FI-00029 HUS, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland. Electronic address: eero.kajantie@helsinki.fi.
⁵ Department of Psychology and Logopedics, University of Helsinki, Faculty of Medicine, P.O.Box 63, FI-00014 University of Helsinki, Finland. Electronic address: anukatriina.pesonen@helsinki.fi.
⁶ Department of Psychology and Logopedics, University of Helsinki, Faculty of Medicine, P.O.Box 63, FI-00014 University of Helsinki, Finland. Electronic address: katri.raikkonen@helsinki.fi.
⁷ Terveystalo Oy, Asemakatu 22-24, FI-70100 Kuopio, Finland. Electronic address: pekka.taipale@terveystalo.com.
⁸ Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Haartmaninkatu 2, P.O. Box 140, FI-00029 HUS, Finland. Electronic address: pia.villa@helsinki.fi.
⁹ Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, P.O. Box 63, FI-00014 University of Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, P.O.Box 20, FI-00014 University of Helsinki, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital, PO Box 2000, FI-33521 Tampere, Finland; Faculty of Medicine and Life Sciences, P.O. Box 100, FI-33014 University of Tampere, Finland. Electronic address: hannele.laivuori@staff.uta.fi.

PMID: 30177071
DOI: 10.1016/j.preghy.2018.04.003

Abstract

Objectives: Our first aim was to study the longitudinal changes of serum placental growth factor (PlGF) concentration between 12⁺⁰ and 28⁺⁰ weeks of gestation in the prospective PREDO cohort. Our second aim was to study the effect of low-dose acetylsalicylic acid (LDA; 100 mg/day), started before the 14th week of gestation, on PlGF concentration.

Study design: Blood samples were collected at 12⁺⁰-14⁺⁰, 18⁺⁰-20⁺⁰ and 26⁺⁰-28⁺⁰ weeks of gestation in 101 women without and 309 with clinical risk factors for pre-eclampsia. Risk-women were divided into two groups: to those who had medium risk for pre-eclampsia and to those who had high risk for pre-eclampsia. Finally there were seven groups according to risk, treatment (no prevention/placebo/LDA) and outcome measure pre-eclampsia. Longitudinal changes in the PlGF concentration between groups were compared. To investigate the effect of LDA on serum PlGF concentration, placebo (N = 62) and LDA (N = 61) groups were compared. A repeated measures ANOVA was used to analyze differences in PlGF levels between the groups.

Results: The increase in serum PlGF concentration was higher in LDA than in placebo group (time × group effect, p = 0.046). The increase in serum PlGF concentration during pregnancy was lower in high-risk women who had placebo and developed pre-eclampsia and in medium-risk women who developed pre-eclampsia compared to the other women (time × group effect, p < 0.001). There were no differences in PlGF change between low-risk women, medium-risk women who did not develop pre-eclampsia, high-risk women in the placebo group without pre-eclampsia and high-risk women in the LDA group with and without pre-eclampsia (p = 0.15).

Conclusions: Our finding suggests an association between LDA started before 14 weeks of gestation and higher increase in serum PlGF concentration.

Keywords: Aspirin; Low-dose acetylsalicylic acid; Placental growth factor; Pre-eclampsia.

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The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

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The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

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