doi: 10.1016/0014-4827(86)90505-7.
Tumor promoters and diacylglycerol activate the Na+/H+ antiporter of sea urchin eggs
- PMID: 3017737
- DOI: 10.1016/0014-4827(86)90505-7
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Tumor promoters and diacylglycerol activate the Na+/H+ antiporter of sea urchin eggs
Exp Cell Res.
1986 Sep.
Abstract
Various tumor promoters (TPA, lyngbyatoxin and aplysiatoxin) and diacylglycerol induced cytoplasmic alkalinization of sea urchin eggs independently of intracellular Ca2+ release. This response stimulated protein synthesis and was blocked by amiloride or a lack of extracellular Na+, procedures which inhibit the Na+/H+ antiporter. These results suggest that the antiporter which is responsible for cytoplasmic alkalinization in sea urchin eggs is activated directly or indirectly by protein kinase C in a Ca2+-independent manner.
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