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. 2018 Dec;129(3):582-588.
doi: 10.1016/j.radonc.2018.08.016. Epub 2018 Aug 31.

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

Pierre Montay-Gruel  1 , Audrey Bouchet  2 , Maud Jaccard  3 , David Patin  3 , Raphael Serduc  4 , Warren Aim  2 , Kristoffer Petersson  5 , Benoit Petit  1 , Claude Bailat  3 , Jean Bourhis  1 , Elke Bräuer-Krisch  6 , Marie-Catherine Vozenin  7
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X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

Pierre Montay-Gruel et al. Radiother Oncol. 2018 Dec.

Abstract

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.

Keywords: Cognitive impairment; Radiation-induced brain injury; Synchrotron radiation; Ultra-high dose-rate X-ray radiation.

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