Neonatal Antibiotic Use: How Much Is Too Much?

doi:10.1542/peds.2018-1942

Comment

. 2018 Sep;142(3):e20181942.

doi: 10.1542/peds.2018-1942.

Neonatal Antibiotic Use: How Much Is Too Much?

Dustin D Flannery¹, Karen M Puopolo²

Affiliations

¹ Division of Neonatology and Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Pennsylvania Hospital, Philadelphia, Pennsylvania; and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania flanneryd@email.chop.edu.
² Division of Neonatology and Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Pennsylvania Hospital, Philadelphia, Pennsylvania; and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

PMID: 30177518
PMCID: PMC6317556
DOI: 10.1542/peds.2018-1942

Comment

Neonatal Antibiotic Use: How Much Is Too Much?

Dustin D Flannery et al. Pediatrics. 2018 Sep.

. 2018 Sep;142(3):e20181942.

doi: 10.1542/peds.2018-1942.

Authors

Dustin D Flannery¹, Karen M Puopolo²

Affiliations

¹ Division of Neonatology and Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Pennsylvania Hospital, Philadelphia, Pennsylvania; and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania flanneryd@email.chop.edu.
² Division of Neonatology and Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Pennsylvania Hospital, Philadelphia, Pennsylvania; and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

PMID: 30177518
PMCID: PMC6317556
DOI: 10.1542/peds.2018-1942

No abstract available

PubMed Disclaimer

Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: Dr Puopolo is a faculty member of the Vermont Oxford Network’s Internet-Based Newborn Improvement Collaborative for Quality “Choosing Antibiotics Wisely”; and Dr Flannery has indicated he has no potential conflicts of interest to disclose.

Comment on

Variations in Neonatal Antibiotic Use.
Schulman J, Profit J, Lee HC, Dueñas G, Bennett MV, Parucha J, Jocson MAL, Gould JB. Schulman J, et al. Pediatrics. 2018 Sep;142(3):e20180115. doi: 10.1542/peds.2018-0115. Pediatrics. 2018. PMID: 30177514 Free PMC article.

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References

1. Centers for Disease Control and Prevention Antibiotic/antimicrobial resistance. Available at: https://www.cdc.gov/drugresistance. Accessed May 23, 2018
1. Cordero L, Ayers LW. Duration of empiric antibiotics for suspected early-onset sepsis in extremely low birth weight infants. Infect Control Hosp Epidemiol. 2003;24(9):662–666 - PubMed
1. Cotten CM, Taylor S, Stoll B, et al. ; NICHD Neonatal Research Network . Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123(1):58–66 - PMC - PubMed
1. Chiu CH, Michelow IC, Cronin J, Ringer SA, Ferris TG, Puopolo KM. Effectiveness of a guideline to reduce vancomycin use in the neonatal intensive care unit. Pediatr Infect Dis J. 2011;30(4):273–278 - PubMed
1. Ting JY, Synnes A, Roberts A, et al. ; Canadian Neonatal Network Investigators . Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatr. 2016;170(12):1181–1187 - PubMed

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[1] Centers for Disease Control and Prevention Antibiotic/antimicrobial resistance. Available at: https://www.cdc.gov/drugresistance. Accessed May 23, 2018

[2] Centers for Disease Control and Prevention Antibiotic/antimicrobial resistance. Available at: https://www.cdc.gov/drugresistance. Accessed May 23, 2018

[3] Cordero L, Ayers LW. Duration of empiric antibiotics for suspected early-onset sepsis in extremely low birth weight infants. Infect Control Hosp Epidemiol. 2003;24(9):662–666 - PubMed

[4] Cordero L, Ayers LW. Duration of empiric antibiotics for suspected early-onset sepsis in extremely low birth weight infants. Infect Control Hosp Epidemiol. 2003;24(9):662–666 - PubMed

[5] Cotten CM, Taylor S, Stoll B, et al. ; NICHD Neonatal Research Network . Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123(1):58–66 - PMC - PubMed

[6] Cotten CM, Taylor S, Stoll B, et al. ; NICHD Neonatal Research Network . Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123(1):58–66 - PMC - PubMed

[7] Chiu CH, Michelow IC, Cronin J, Ringer SA, Ferris TG, Puopolo KM. Effectiveness of a guideline to reduce vancomycin use in the neonatal intensive care unit. Pediatr Infect Dis J. 2011;30(4):273–278 - PubMed

[8] Chiu CH, Michelow IC, Cronin J, Ringer SA, Ferris TG, Puopolo KM. Effectiveness of a guideline to reduce vancomycin use in the neonatal intensive care unit. Pediatr Infect Dis J. 2011;30(4):273–278 - PubMed

[9] Ting JY, Synnes A, Roberts A, et al. ; Canadian Neonatal Network Investigators . Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatr. 2016;170(12):1181–1187 - PubMed

[10] Ting JY, Synnes A, Roberts A, et al. ; Canadian Neonatal Network Investigators . Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatr. 2016;170(12):1181–1187 - PubMed

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Neonatal Antibiotic Use: How Much Is Too Much?

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Neonatal Antibiotic Use: How Much Is Too Much?

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