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. 2018 Sep 19;38(5):BSR20181257.
doi: 10.1042/BSR20181257. Print 2018 Oct 31.

The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk

Rui Geng  1 , Yuansheng Xu  2 , Wenhao Hu  3 , Hui Zhao  4
Affiliations

The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk

Rui Geng et al. Biosci Rep. .

Abstract

Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case-control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47-3.53), P<0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15-2.24), P=0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26-2.68), P=0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20-1.83), P<0.001) of MMP-1 gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case-control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population.

Keywords: MMP-1; Single Nucleotide Polymorphism; knee OA.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

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