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Review
. 2018 Aug 20:5:220.
doi: 10.3389/fmed.2018.00220. eCollection 2018.

The Growing Incidence of Bullous Pemphigoid: Overview and Potential Explanations

Khalaf Kridin  1 , Ralf J Ludwig  2
Affiliations
Review

The Growing Incidence of Bullous Pemphigoid: Overview and Potential Explanations

Khalaf Kridin et al. Front Med (Lausanne). .

Abstract

Bullous pemphigoid (BP) is the most common type of subepidermal autoimmune bullous diseases. BP characteristically affects the elderly and is seen mainly in patients older than 70 years. While the annual incidence of BP has been estimated to be between 2.4 and 23 cases per million in the general population, it rises exponentially to 190-312 cases per million in individuals older than 80 years. In addition, a growing body of evidence reports a remarkable trend of increased incidence of BP, showing a 1.9- to 4.3-fold rise over the past two decades. This demonstrable increase warrants a higher awareness of the increased risk to develop BP. This review summarizes the current understanding of the epidemiological features of BP and sheds light on the putative explanations for its growing incidence.

Keywords: DPP-4 inhibitors; bullous pemphigoid; epidemiology; explanation; incidence; longevity; review of literature.

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References

    1. Hammers CM, Stanley JR. Mechanisms of disease: pemphigus and bullous pemphigoid. Annu Rev Pathol Mech Dis. (2016) 11:175–97. 10.1146/annurev-pathol-012615-044313 - DOI - PMC - PubMed
    1. Bernard P, Vaillant L, Labeille B, Bedane C, Arbeille B, Denoeux JP, et al. . Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group. Arch Dermatol. (1995) 131:48–52. 10.1001/archderm.1995.01690130050009 - DOI - PubMed
    1. Marazza G, Pham HC, Schärer L, Pedrazzetti PP, Hunziker T, Trüeb RM, et al. . Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study. Br J Dermatol. (2009) 161:861–8. 10.1111/j.1365-2133.2009.09300.x - DOI - PubMed
    1. Jung M, Kippes W, Messer G, Zillikens D, Rzany B. Increased risk of bullous pemphigoid in male and very old patients: a population-based study on incidence. J Am Acad Dermatol. (1999) 41:266–8. - PubMed
    1. Kridin K. Subepidermal autoimmune bullous diseases: overview, epidemiology, and associations. Immunol Res. (2018) 66:6–17. 10.1007/s12026-017-8975-2 - DOI - PubMed

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