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. 1977 Jul;61(4):745-8.

Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration

D D Von Hoff, J S Penta, L J Helman, M Slavik
  • PMID: 301783

Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration

D D Von Hoff et al. Cancer Treat Rep. 1977 Jul.

Abstract

A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

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