The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein

Abstract

1. Øie-Tozer's model can be used to derive changes in the distribution of drugs in relation to changes in the concentration of drug binding plasma proteins. 2. Concerns have been raised that the model is invalid for this purpose because it does not account for active drug transport, pH differences between fluids and extracellular tissue binding. 3. Here, it is demonstrated that these imperfections do not affect the outcome of the calculation.

Keywords: Disposition; distribution; dose fractions; drug concentration; free fraction; model imperfections; pharmacokinetics.