Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

Meredith L Stone¹, Katherine B Chiappinelli¹, Huili Li¹, Lauren M Murphy¹, Meghan E Travers¹, Michael J Topper¹, Dimitrios Mathios², Michael Lim², Ie-Ming Shih³, Tian-Li Wang⁴, Chien-Fu Hung⁴, Vipul Bhargava⁵, Karla R Wiehagen⁶, Glenn S Cowley⁵, Kurtis E Bachman⁷, Reiner Strick⁸, Pamela L Strissel⁸, Stephen B Baylin⁹, Cynthia A Zahnow⁹

Affiliations

¹ Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
² Department of Neurosurgery, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
³ Department of Gynecology and Obstetrics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
⁴ Department of Pathology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
⁵ Discovery Sciences, Janssen Research & Development, Spring House, PA 19477.
⁶ Immuno-Oncology Discovery, Janssen Research & Development, Spring House, PA 19477.
⁷ Oncology Janssen Research & Development, Spring House, PA 19477.
⁸ Laboratory for Molecular Medicine, Department of Gynaecology and Obstetrics, University-Clinic Erlangen, 91054 Erlangen, Germany.
⁹ Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287; zahnoci@jhmi.edu sbaylin@jhmi.edu.

PMID: 30181297
PMCID: PMC6140504
DOI: 10.1073/pnas.1811015115

Comment

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

Meredith L Stone et al. Proc Natl Acad Sci U S A. 2018.

. 2018 Sep 11;115(37):E8583-E8584.

doi: 10.1073/pnas.1811015115. Epub 2018 Sep 4.

Authors

Affiliations

¹ Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
² Department of Neurosurgery, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
³ Department of Gynecology and Obstetrics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
⁴ Department of Pathology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
⁵ Discovery Sciences, Janssen Research & Development, Spring House, PA 19477.
⁶ Immuno-Oncology Discovery, Janssen Research & Development, Spring House, PA 19477.
⁷ Oncology Janssen Research & Development, Spring House, PA 19477.
⁸ Laboratory for Molecular Medicine, Department of Gynaecology and Obstetrics, University-Clinic Erlangen, 91054 Erlangen, Germany.
⁹ Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287; zahnoci@jhmi.edu sbaylin@jhmi.edu.

PMID: 30181297
PMCID: PMC6140504
DOI: 10.1073/pnas.1811015115

No abstract available

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Conflict of interest statement

Conflict of interest statement: C.A.Z. and S.B.B. have a collaborative research agreement with Janssen. V.B., K.R.W., G.S.C., and K.E.B. are employed by Janssen.

Comment on

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.
Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, Strick R, Strissel PL, Baylin SB, Zahnow CA. Stone ML, et al. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10981-E10990. doi: 10.1073/pnas.1712514114. Epub 2017 Dec 4. Proc Natl Acad Sci U S A. 2017. PMID: 29203668 Free PMC article.
Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors.
Haffner MC, Taheri D, Luidy-Imada E, Palsgrove DN, Eich ML, Netto GJ, Matoso A, Nirschl TR, Zheng Q, Hicks JL, Nelson WG, De Marzo AM, Marchionni L, Drake CG, Yegnasubramanian S. Haffner MC, et al. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8580-E8582. doi: 10.1073/pnas.1803292115. Epub 2018 Sep 4. Proc Natl Acad Sci U S A. 2018. PMID: 30181298 Free PMC article. No abstract available.

References

1. Haffner MC, et al. Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors. Proc Natl Acad Sci USA. 2018;115:E8580–E8582. - PMC - PubMed
1. Stone ML, et al. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. Proc Natl Acad Sci USA. 2017;114:E10981–E10990. - PMC - PubMed
1. Topper MJ, et al. Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer. Cell. 2017;171:1284–1300.e21. - PMC - PubMed
1. Chiappinelli KB, et al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell. 2015;162:974–986. - PMC - PubMed
1. Ghoshal K, et al. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol. 2005;25:4727–4741. - PMC - PubMed

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Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

Affiliations

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

Authors

Affiliations

Conflict of interest statement

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References

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