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Review
. 2018 Aug 13;18(4):e27.
doi: 10.4110/in.2018.18.e27. eCollection 2018 Aug.

Damage-Associated Molecular Patterns in Inflammatory Diseases

Jong Seong Roh  1 , Dong Hyun Sohn  1
Affiliations
Review

Damage-Associated Molecular Patterns in Inflammatory Diseases

Jong Seong Roh et al. Immune Netw. .

Abstract

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.

Keywords: Damage-associated molecular patterns; Inflammation; Inflammatory diseases; Pattern recognition receptors.

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Conflict of interest statement

Conflict of Interest: The authors declare no potential conflicts of interest.

Figures

Figure 1
Figure 1. DAMPs as biomarkers and potential therapeutic targets.
DAMPs are released upon cellular stress or tissue injury and activate the innate immune system by interacting with PRRs to produce proinflammatory cytokines. Chronic inflammation can contribute to the development of various inflammatory diseases, which in turn stimulate the secretion of DAMPs, thus establishing a vicious cycle of DAMPs production and inflammation.
See this image and copyright information in PMC

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