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Comment
. 2018 Sep 4;28(3):330-331.
doi: 10.1016/j.cmet.2018.08.017.

A Mitochondrial-Derived Peptide Exercises the Nuclear Option

Kailash C Mangalhara  1 , Gerald S Shadel  2
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A Mitochondrial-Derived Peptide Exercises the Nuclear Option

Kailash C Mangalhara et al. Cell Metab. .
Free article

Abstract

The vast majority of mitochondrial proteins are encoded by nuclear genes, giving the nucleus ultimate control of mitochondrial biogenesis, dynamics, and function. However, in this issue Kim et al. (2018) demonstrate a reversal of fortune, whereby an mtDNA-encoded peptide, MOTS-c, is targeted to the nucleus to signal changes in gene expression.

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