Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Sep 4;28(3):334-336.
doi: 10.1016/j.cmet.2018.08.018.

Metformin: An Old Dog with a New Trick?

Claudia C Dos Santos  1 , Bharat Gopal  2 , Subodh Verma  3
Affiliations
Free article
Comment

Metformin: An Old Dog with a New Trick?

Claudia C Dos Santos et al. Cell Metab. .
Free article

Abstract

Idiopathic pulmonary fibrosis (IPF) remains an important medical challenge, but recent translational data have provided clues implicating deficient AMPK signaling in persistently activated myelofibroblasts within fibrotic foci. A new study in Nature Medicine reports that pharmacological activation of AMPK with metformin can reverse established fibrosis by facilitating deactivation and apoptosis of myofibroblasts.

PubMed Disclaimer

Comment on

  • Metformin reverses established lung fibrosis in a bleomycin model.
    Rangarajan S, Bone NB, Zmijewska AA, Jiang S, Park DW, Bernard K, Locy ML, Ravi S, Deshane J, Mannon RB, Abraham E, Darley-Usmar V, Thannickal VJ, Zmijewski JW. Rangarajan S, et al. Nat Med. 2018 Aug;24(8):1121-1127. doi: 10.1038/s41591-018-0087-6. Epub 2018 Jul 2. Nat Med. 2018. PMID: 29967351 Free PMC article.

LinkOut - more resources