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. 1986 Jul;9(3):269-78.

Preliminary characterization of a fast-growing strain of human hepatitis A virus

M Divizia, F Ruggeri, J Hentschel, B Flehmig, A Panà, R Perez-Bercoff
  • PMID: 3018450

Preliminary characterization of a fast-growing strain of human hepatitis A virus

M Divizia et al. Microbiologica. 1986 Jul.

Abstract

A fast-growing strain of Human Hepatitis A (HHA) virus was selected by progressively shortening by the time between serial passages of the isolate in the simian cell line Frp/3. The virus so selected infected 90-95% of the cells in 7-10 days, and developed a strong cytopathic effect (CPE). The synthesis of HHA-specific antigens and the CPE were neutralized simultaneously by standard anti-HHA sera. This fast-growing strain has the characteristics of a picornavirus.

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