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. 1985 Aug;5(8):2142-6.
doi: 10.1128/mcb.5.8.2142-2146.1985.

Polyomavirus mutation that confers a cell-specific cis advantage for viral DNA replication

V De Simone, G La Mantia, L Lania, P Amati

Polyomavirus mutation that confers a cell-specific cis advantage for viral DNA replication

V De Simone et al. Mol Cell Biol. 1985 Aug.

Abstract

The structural and biological properties of a polyomavirus mutant selected in Friend erythroleukemic cells were investigated. The growth efficiency of this mutant (PyFL78) was compared with that of the parental PyA2 strain by a growth competition assay in Friend erythroleukemic and 3T3 (or 3T6) cell lines. The results reveal that PyFL78 displays a cis-acting growth advantage over the PyA2 parental strain in Friend erythroleukemic cells but not in 3T3 or 3T6 cells. This cell-specific cis advantage is shown to be due to modifications within the polyomavirus noncoding regulatory region.

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