. 2018 Sep 5:362:k3581.

doi: 10.1136/bmj.k3581.

Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline

Kari A O Tikkinen^{1

2}, Philipp Dahm³, Lyubov Lytvyn⁴, Anja F Heen⁵, Robin W M Vernooij⁶, Reed A C Siemieniuk⁴, Russell Wheeler⁷, Bill Vaughan⁸, Awah Cletus Fobuzi^{9

10}, Marco H Blanker¹¹, Noelle Junod¹², Johanna Sommer¹³, Jérôme Stirnemann¹⁴, Manabu Yoshimura¹⁵, Reto Auer^{16

17}, Helen MacDonald¹⁸, Gordon Guyatt⁴, Per Olav Vandvik⁵, Thomas Agoritsas^{4

14

19}

Affiliations

¹ Department of Urology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland kari.tikkinen@gmail.com.
² Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.
³ Urology Section, Minneapolis VAMC and Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
⁵ Department of Medicine, Innlandet Hospital Trust-division, Gjøvik, Norway.
⁶ Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
⁷ Cochrane Consumers, London, UK.
⁸ Citizens United for Evidence-Based Medicine, Virginia, USA.
⁹ Cameroon Consumer Service Organization (CamCoSO), Bamenda, Cameroon.
¹⁰ Coalition of Civil Society Organizations Cameroon, Bamenda, Cameroon.
¹¹ Department of General Practice and Elderly Medicine, University Medical Centre-Groningen, University of Groningen, Groningen, The Netherlands.
¹² Institute of Primary Care, Geneva University Hospitals, Geneva, Switzerland.
¹³ Unit of Primary Care Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
¹⁴ Division General Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.
¹⁵ School of Medicine, University of Miyazaki, Miyazaki, Japan.
¹⁶ Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
¹⁷ Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.
¹⁸ The BMJ, London, UK.
¹⁹ Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland.

PMID: 30185545
PMCID: PMC6283372
DOI: 10.1136/bmj.k3581

Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline

Kari A O Tikkinen et al. BMJ. 2018.

. 2018 Sep 5:362:k3581.

doi: 10.1136/bmj.k3581.

Authors

Affiliations

¹ Department of Urology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland kari.tikkinen@gmail.com.
² Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.
³ Urology Section, Minneapolis VAMC and Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
⁵ Department of Medicine, Innlandet Hospital Trust-division, Gjøvik, Norway.
⁶ Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
⁷ Cochrane Consumers, London, UK.
⁸ Citizens United for Evidence-Based Medicine, Virginia, USA.
⁹ Cameroon Consumer Service Organization (CamCoSO), Bamenda, Cameroon.
¹⁰ Coalition of Civil Society Organizations Cameroon, Bamenda, Cameroon.
¹¹ Department of General Practice and Elderly Medicine, University Medical Centre-Groningen, University of Groningen, Groningen, The Netherlands.
¹² Institute of Primary Care, Geneva University Hospitals, Geneva, Switzerland.
¹³ Unit of Primary Care Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
¹⁴ Division General Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.
¹⁵ School of Medicine, University of Miyazaki, Miyazaki, Japan.
¹⁶ Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
¹⁷ Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.
¹⁸ The BMJ, London, UK.
¹⁹ Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland.

PMID: 30185545
PMCID: PMC6283372
DOI: 10.1136/bmj.k3581

No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: All authors have completed the BMJ Rapid Recommendations interests disclosure form, and a detailed description of all disclosures is reported in appendix 1. As with all BMJ Rapid Recommendations, the executive team and The BMJ judged that no panel member had any financial conflict of interest. Professional and academic interests are minimised as much as possible, while maintaining necessary expertise on the panel to make fully informed decisions.

Figures

**Fig 2**
Characteristics of patients and trials included in systematic review of the use of the prostate-specific antigen (PSA) test for prostate cancer screening.

**Fig 3**
Practical issues about use of prostate-specific antigen (PSA) testing and biopsy for prostate cancer screening

See this image and copyright information in PMC

Comment in

Guideline: Experts recommend against prostate cancer screening with prostate-specific antigen test.
Fletcher RH. Fletcher RH. Ann Intern Med. 2019 Jan 15;170(2):JC2. doi: 10.7326/ACPJC-2019-170-2-002. Ann Intern Med. 2019. PMID: 30641553 No abstract available.

References

1. Ilic D, Djulbegovic M, Jung JH, et al. Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis. BMJ 2018;362:k3519 10.1136/bmj.k3519. - DOI - PMC - PubMed
1. Martin RM, Donovan JL, Turner EL, et al. CAP Trial Group Effect of a low-intensity PSA-based screening intervention on prostate cancer mortality: The CAP Randomized Clinical Trial. JAMA 2018;319:883-95. 10.1001/jama.2018.0154 - DOI - PMC - PubMed
1. Global Burden of Disease Cancer Collaboration The Global burden of cancer 2013. JAMA Oncol 2015;1:505-27. 10.1001/jamaoncol.2015.0735. - DOI - PMC - PubMed
1. Østerø Í Jákupsstovu J, Brodersen J. Do men with lower urinary tract symptoms have an increased risk of advanced prostate cancer? BMJ 2018;361:k1202. 10.1136/bmj.k1202. - DOI - PubMed
1. Schröder FH, Hugosson J, Roobol MJ, et al. ERSPC Investigators Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. Lancet 2014;384:2027-35. 10.1016/S0140-6736(14)60525-0. - DOI - PMC - PubMed

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Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline

Affiliations

Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline

Authors

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Conflict of interest statement

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Medical

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