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Comment
. 2018 Oct;8(10):1203-1204.
doi: 10.1158/2159-8290.CD-NB2018-117. Epub 2018 Sep 5.

With GBM, T Cells May Be Stuck in Bone Marrow

No authors listed
Comment

With GBM, T Cells May Be Stuck in Bone Marrow

No authors listed. Cancer Discov. 2018 Oct.

Abstract

A recent study uncovered a possible explanation for why patients with glioblastoma often have low levels of circulating T cells: The cells become sequestered in the bone marrow in high numbers, and are likely unable to leave because they lack the S1P1 receptor. The findings could lead to the development of more-effective immunotherapies.

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  • Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.
    Chongsathidkiet P, Jackson C, Koyama S, Loebel F, Cui X, Farber SH, Woroniecka K, Elsamadicy AA, Dechant CA, Kemeny HR, Sanchez-Perez L, Cheema TA, Souders NC, Herndon JE, Coumans JV, Everitt JI, Nahed BV, Sampson JH, Gunn MD, Martuza RL, Dranoff G, Curry WT, Fecci PE. Chongsathidkiet P, et al. Nat Med. 2018 Sep;24(9):1459-1468. doi: 10.1038/s41591-018-0135-2. Epub 2018 Aug 13. Nat Med. 2018. PMID: 30104766 Free PMC article.

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