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Case Reports
. 2018 Nov 1;80(10):1558-1561.
doi: 10.1292/jvms.18-0395. Epub 2018 Sep 5.

Uterine metastatic rhabdomyosarcoma in a scimitar-horned oryx (Oryx dammah)

Du-Min Go  1 , Sang-Ho Woo  1 , Su-Hyung Lee  2 , Soo-Whan Kwon  3 , Dong-Hee Chung  3 , Soong-Hee Youn  3 , Eun Jung  3 , Dae-Yong Kim  1
Affiliations
Case Reports

Uterine metastatic rhabdomyosarcoma in a scimitar-horned oryx (Oryx dammah)

Du-Min Go et al. J Vet Med Sci. .

Abstract

A 13-year-old female scimitar-horned oryx (Oryx dammah) died after progressive anorexia, weight loss, and depression. The necropsy showed that the retroperitoneum was compressed by a large white-to-tan uterine mass and on several sections of the mass, the uterine wall was markedly thickened because of ill-defined transmural tumor tissue. Metastatic nodules were detected in the omentum, mesentery, diaphragm, and lung. The genital tract and pulmonary and abdominal nodules exhibited highly pleomorphic sarcoma. The primary and metastatic neoplastic cells showed positive results for vimentin, desmin, and sarcomeric actin, and negative results for smooth muscle actin. Uterine metastatic rhabdomyosarcoma was diagnosed on the basis of the gross, histopathology and immunohistochemistry results.

Keywords: immunohistochemistry; oryx; rhabdomyosarcoma; uterus.

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Figures

Fig. 1.
Fig. 1.
Rhabdomyosarcoma, uterus, scimitar-horned oryx (Oryx dammah). On the right uterine horn mass (asterisk), the uterine wall is markedly thickened because of ill-defined transmural tumor tissue involving serosa. On the luminal side of the uterine body and cervix (arrow), a large white-to-tan mass is present.
Fig. 2.
Fig. 2.
Histology of rhabdomyosarcoma in a scimitar-horned oryx (Oryx dammah). A. The uterine mass is composed of pleomorphic neoplastic cells arranged in haphazard or interlacing patterns. H&E. Bar=200 µm. B. The neoplastic cells show marked pleomorphism. Note the eccentric and bizarre nuclei containing 1 or more prominent nucleoli. H&E. Bar=50 µm. C and D. The neoplasm metastasized to the diaphragm (C) and lung (D). H&E. Bar=200 µm.
Fig. 3.
Fig. 3.
Immunohistochemistry of rhabdomyosarcoma in a scimitar-horned oryx (Oryx dammah). The neoplastic cells are positive for vimentin (A) and desmin (B). The neoplastic cells are negative for smooth muscle actin (C) but positive for sarcomeric actin (D). Note the positive (C) and negative (D) staining of the vascular smooth muscles (arrows). Bar=50 µm (applies to A, B, C, and D).
See this image and copyright information in PMC

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