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. 1986 Aug;322(6080):609-12.
doi: 10.1038/322609a0.

Bovine papillomavirus genome elicits skin tumours in transgenic mice

M Lacey, S Alpert, D Hanahan

Bovine papillomavirus genome elicits skin tumours in transgenic mice

M Lacey et al. Nature. 1986 Aug.

Abstract

Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA.

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