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Review
. 2018 Sep;31(5):309-316.
doi: 10.1055/s-0038-1642048. Epub 2018 Sep 4.

Colorectal Lymphoma: A Review

Nathan D Gay  1 , Andy Chen  1 , Craig Y Okada  1   2
Affiliations
Review

Colorectal Lymphoma: A Review

Nathan D Gay et al. Clin Colon Rectal Surg. 2018 Sep.

Abstract

Non-Hodgkin lymphoma (NHL) that primarily involves the colon is rare and should be distinguished from the more common systemic nodal lymphoma. It has unique clinical expectations and management consideration. Different histologic subtypes of NHL involve the colon, which varies in the clinical behavior and likelihood of obtaining durable remissions with treatment. This article will review the current understanding of the different histologic subtypes of primary colorectal lymphoma and propose management algorithms.

Keywords: extranodal; gastrointestinal; large bowel; primary colorectal lymphoma.

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Figures

Fig. 1
Fig. 1
Treatment algorithm for primary colorectal diffuse large B cell lymphoma. Management of diffuse large B cell lymphoma involves treatment with an R-CHOP–like regimen. Surgery for limited-stage disease allows less chemotherapy use, thus reducing chemotherapy-related toxicities.
Fig. 2
Fig. 2
Treatment algorithm for primary colorectal follicular lymphoma. Management of localized early-stage disease would include resection or radiation. Advanced-stage disease is best managed with immunochemotherapy.
Fig. 3
Fig. 3
Treatment algorithm for primary colorectal mantle cell lymphoma. Aggressive treatment of mantle cell lymphoma involves use of a cytarabine-based multiagent immunochemotherapy regimen. Surgical resection of early-stage disease may improve clinical outcomes and reduce the need for an extended immunochemotherapy treatment course.
See this image and copyright information in PMC

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