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. 2018 Aug 21:10:256.
doi: 10.3389/fnagi.2018.00256. eCollection 2018.

Effects of Gender and Apolipoprotein E on Novelty MMN and P3a in Healthy Elderly and Amnestic Mild Cognitive Impairment

Lijuan Gao  1 , Jiu Chen  1 , Lihua Gu  1 , Hao Shu  1 , Zan Wang  1 , Duan Liu  1 , Yanna Yan  2 , Zhijun Zhang  1   2
Affiliations

Effects of Gender and Apolipoprotein E on Novelty MMN and P3a in Healthy Elderly and Amnestic Mild Cognitive Impairment

Lijuan Gao et al. Front Aging Neurosci. .

Abstract

Background: The apolipoprotein E epsilon4 (ApoE ε4) allele and female gender may be important risk factors for the development of Alzheimer's disease and amnestic mild cognitive impairment (aMCI). Novelty mismatch negativity (MMN) represents the pre-attentive index of deviance detection and P3a represents the attention orienting response. Furthermore, MMN and P3a components have been reported to be potential markers in aMCI. Therefore, this study will investigate the effects of gender and ApoE on auditory novelty MMN and P3a and their relationship to neuropsychological performance in aMCI. Methods: Thirty nine aMCI subjects and 44 controls underwent neuropsychological assessment and ApoE genotyping. Novelty MMN and P3a components were investigated during an auditory novelty oddball task. Results: Firstly, novelty MMN latency was significantly shorter in aMCI than in healthy control (HC) group. Secondly, novelty MMN latency was negatively correlated with episodic memory in aMCI, but not in HC. Novelty P3a latency was negatively correlated with information processing speed in all subjects. For gender effect, novelty MMN latency was shorter in aMCI females than in HC females. Moreover, novelty P3a amplitudes were lower in males than in females in both aMCI and HC. For the effect of ApoE status, novelty MMN latency was shorter in aMCI ApoE ε4- than HC ApoE ε4-. Conclusion: aMCI presents altered pre-attentive processing indexed by novelty MMN components. Furthermore, there may be a compensatory mechanism on the impaired processing in aMCI. It further suggests that aMCI female and ApoE ε4- recruited the compensatory mechanism.

Keywords: amnestic mild cognitive impairment; apolipoprotein E; event-related potential; gender; novelty P3a; novelty mismatch negativity.

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Figures

FIGURE 1
FIGURE 1
Correlation of novelty MMN latency with episodic memory in aMCI and HC. Scattergram represents correlation between episodic memory Z score (adjusted scores) and novelty MMN latency (adjusted scores) in HC (black line) and aMCI (red line). Note that the data of the latency is mean latency from the Fz, FCz, Cz electrodes. The figure used the adjusted data controlling for the effects of age, gender, education years, ApoE status, and group.
FIGURE 2
FIGURE 2
Correlation of novelty P3a latency with information processing speed in all subjects. Scattergram represents correlation between information processing speed Z score (adjusted scores) and novelty P3a latency (adjusted scores) in all subjects (black line). Note that the data of the latency is mean latency from the Fz, FCz, Cz electrodes. The figure used the adjusted data controlling for the effects of age, gender, education years, ApoE status, and group.
See this image and copyright information in PMC

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