Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Aug 22:9:893.
doi: 10.3389/fphar.2018.00893. eCollection 2018.

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Aminu Mohammed  1   2 , Md Shahidul Islam  2
Affiliations
Review

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Aminu Mohammed et al. Front Pharmacol. .

Abstract

Spices possess tremendous therapeutic potential including hypoglycemic action, attributed to their bioactive ingredients. However, there is no study that critically reviewed the hypoglycemic potency, safety and the bioavailability of the spice-derived bioactive ingredients (SDBI). Therefore, the aim of the study was to comprehensively review all published studies regarding the hypoglycemic action of SDBI with the purpose to assess whether the ingredients are potential hypoglycemic agents or adjuvant. Factors considered were concentration/dosages used, the extent of blood glucose reduction, the IC50 values, and the safety concern of the SDBI. From the results, cinnamaldehyde, curcumin, diosgenin, thymoquinone (TQ), and trigonelline were showed the most promising effects and hold future potential as hypoglycemic agents. Conclusively, future studies should focus on improving the tissue and cellular bioavailability of the promising SDBI to achieve greater potency. Additionally, clinical trials and toxicity studies are with these SDBI are warranted.

Keywords: adjuvant; diabetes mellitus; hypoglycemic; in vitro; in vivo; spices.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Possible mechanism of hypoglycemic action by spice-derived ingredients.
See this image and copyright information in PMC

References

    1. Abdel Aziz M. T., El-Asmar M. F., Rezq A. M., Mahfouz S. M., Wassef M. A., Fouad H. H., et al. . (2013). The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study). Diabetol. Metab. Syndr. 5, 1–14. 10.1186/1758-5996-5-75 - DOI - PMC - PubMed
    1. Abdelmeguid N. E., Fakhoury R., Kamal S. M., Al Wafai R. J. (2010). Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. J. Diabetes 2, 256–266. 10.1111/j.1753-0407.2010.00091.x - DOI - PubMed
    1. Abdul-Hamid M., Moustafa N. (2013). Protective effect of curcumin on histopathology and ultrastructure of pancreas in the alloxan treated rats for induction of diabetes. J. Basic Appl. Zool. 66, 169–179. 10.1016/j.jobaz.2013.07.003 - DOI
    1. Abukhader M. M. (2012). The effect of route of administration in thymoquinone toxicity in male and female rats. Indian J. Pharm. Sci. 74, 195–200. 10.4103/0250-474X.106060 - DOI - PMC - PubMed
    1. Acar A., Akil E., Alp H., Evliyaoglu O., Kibrisli E., Inal A., et al. . (2012). Oxidative damage is ameliorated by curcumin treatment in brain and sciatic nerve of diabetic rats. Int. J. Neurosci. 122, 367–372. 10.3109/00207454.2012.657380 - DOI - PubMed

LinkOut - more resources