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Case Reports
. 2018 Jul;8(3):e168-e173.
doi: 10.1055/s-0038-1669938. Epub 2018 Sep 4.

Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience

Keliana O'Mara  1 , Michael D Weiss  2
Affiliations
Case Reports

Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience

Keliana O'Mara et al. AJP Rep. 2018 Jul.

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in neonates. Therapeutic hypothermia reduces the risk of death or disability. Providing optimal sedation while neonates are undergoing therapeutic hypothermia is likely beneficial but may present therapeutic challenges. There are limited data describing the use of dexmedetomidine for sedation in patients undergoing therapeutic hypothermia. The objective of this study is to evaluate the efficacy and short-term safety of dexmedetomidine infusion for sedation in term neonates undergoing therapeutic hypothermia for HIE.

Keywords: dexmedetomidine; hypoxic-ischemic encephalopathy; neonate; sedation.

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Conflict of interest statement

Disclosure Statement None.

Figures

Fig. 1
Fig. 1
Vital signs over time are shown for a period of 96 hours. The change in the heart rate ( A ), the mean arterial pressure (MAP, B ), and cerebral oximetry ( C ) are shown graphically compared with a baseline vital sign reading prior to infusion of dexmedetomidine. Graphed values represent the mean ± standard deviation (SD).
Fig. 2
Fig. 2
Enteral feeding outcomes. Number of patients receiving any enteral feeds compared with those achieving full enteral feeds over time.
See this image and copyright information in PMC

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