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Review
. 2018 Aug 22:5:113.
doi: 10.3389/fcvm.2018.00113. eCollection 2018.

Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Annemiek Dickhout  1 , Rory R Koenen  1   2
Affiliations
Review

Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Annemiek Dickhout et al. Front Cardiovasc Med. .

Abstract

The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovascular diseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovascular disorders. Various studies have already indicated associations of EV counts and content with cardiovascular diseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.

Keywords: atherosclerosis; diagnostic; endothelial cell; microparticle; monocyte; platelet; vascular remodeling.

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