Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Mar;4(1):30-33.
doi: 10.18502/cmm.4.1.32.

First report of Vulvovaginitis due to Cryptococcus magnus in Iran

Ali Ghajari  1 , Ensieh Lotfali  1 , Maryam Norouzi  1 , Zahra Arab-Mazar  2
Affiliations
Case Reports

First report of Vulvovaginitis due to Cryptococcus magnus in Iran

Ali Ghajari et al. Curr Med Mycol. 2018 Mar.

Abstract

Background and purpose: Cryptococcus. magnus is a non-Cryptococcus neoformans species isolated from certain plants, soil, air, and arctic glaciers.

Case report: This report describes a case of a 23-year-old Iranian female with pruritus and vaginal irritation. Conventional tests and molecular analysis of the samples of vaginal discharge were performed. The mentioned analyses revealed Cryptococcus magnus as the causative agent of vaginal infection. The minimum inhibitory concentration analysis revealed that this species is susceptible to itraconazole, fluconazole, ketoconazole, and amphotericin B. The patient received 200 mg of oral ketoconazole once daily for 10 days. The patient did not show any clinical signs of vaginal infection after six months.

Conclusion: C. magnus was found to have the ability to cause vulvovaginitis. This is the first report of successful detection and treatment of vulvovaginal infection with C. magnus.

Keywords: Cryptococcus magnus; Isolation; Ribosomal 28S DNA sequence.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Cream-colored colonies, slightly mucoid (A), and pink-colored colonies after three days on Sabouraud Dextrose Agar (B)
Figure 2
Figure 2
Ovoid to elongate, single or pairs of cells without pseudomycelium (A); stain according to Indian ink (B), Stain according to Methylene blue (C)
See this image and copyright information in PMC

References

    1. Poth T, Seibold M, Werckenthin C, Hermanns W. First report of a Cryptococcus magnus infection in a cat. Med Mycol. 2010;48(7):1000–4. - PubMed
    1. Randhawa HS, Paliwal DK. Survey of Cryptococcus neoformans in the respiratory tract of patients with bronchopulmonary disorders and in the air. Sabouraudia. 1979;17(4):399–404. - PubMed
    1. Emami S, Foroumadi A, Falahati M, Lotfali E, Rajabalian S, Ebrahimi SA, et al. 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. Bioorg Med Chem Lett. 2008;18(1):141–6. - PubMed
    1. Nagornaya SS, Babich TV, Podgorsky VS, Beharav A, Nevo E, Wasser SP. Yeast interslope divergence in soils and plants of" Evolution Canyon";, Lower Nahal Oren, Mount Carmel, Israel. Israel J Plant Sci. 2003;51(1):55–7.
    1. Pfaller MA, Houston A, Coffmann S. Application of CHROMagar Candida for rapid screening of clinical specimens for Candida albicans, Candida tropicalis, Candida krusei, and Candida (Torulopsis) glabrata. J Clin Microbiol. 1996;34(1):58–61. - PMC - PubMed

Publication types

LinkOut - more resources