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. 2018 Aug 9;2(9):1050-1057.
doi: 10.1210/js.2018-00107. eCollection 2018 Sep 1.

Insulin Resistance Probability Scores for Apparently Healthy Individuals

Fahim Abbasi  1 , Dov Shiffman  2 , Carmen H Tong  2 , James J Devlin  2 , Michael J McPhaul  2
Affiliations

Insulin Resistance Probability Scores for Apparently Healthy Individuals

Fahim Abbasi et al. J Endocr Soc. .

Abstract

Context: Insulin resistance (IR) can progress to type 2 diabetes. Therefore, timely identification of IR could facilitate disease prevention efforts. However, direct measurement of IR is not feasible in a clinical setting.

Objective: Develop a clinically practical probability score to assess IR in apparently healthy individuals based on levels of insulin, C-peptide, and other risk factors.

Design: Cross-sectional study.

Participants: Apparently healthy individuals who volunteered to participate in studies of IR.

Main outcome measure: IR, defined as the top tertile of steady-state plasma glucose during an insulin-suppression test.

Results: In a study of 535 participants, insulin, C-peptide, creatinine, body mass index (BMI), and triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) were independently associated with IR (all P < 0.05) in a model that included age, sex, ethnicity, BMI, blood pressure, insulin, C-peptide, fasting glucose, low-density lipoprotein cholesterol, TG/HDL-C, alanine aminotransferase, and creatinine. For an IR probability score based on a model that included insulin, C-peptide, creatinine, TG/HDL-C, and BMI, the odds ratio was 26.7 (95% CI 14.0 to 50.8) for those with scores >66% compared with those with scores <33%. When only insulin and C-peptide were included in the model, the odds ratio was 15.6 (95% CI 7.5 to 32.4) for those with scores >66% compared with those with scores <33%.

Conclusions: An IR probability score based on insulin, C-peptide, creatinine, TG/HDL-C, and BMI or a score based on only insulin and C-peptide may help assess IR in apparently healthy individuals.

Keywords: C-peptide; insulin; insulin resistance.

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Figures

Figure 1.
Figure 1.
IR according to insulin and C-peptide tertile. The fraction of individuals having IR at each of the nine tertile combinations of insulin and C-peptide is indicated on each bar (number of those with IR/total number).
See this image and copyright information in PMC

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