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. 2018 Sep 20;54(76):10718-10721.
doi: 10.1039/c8cc06010j.

A halogen bond-donor amino acid for organocatalysis in water

Greta Bergamaschi  1 , Luisa Lascialfari, Andrea Pizzi, Maria Isabel Martinez Espinoza, Nicola Demitri, Alberto Milani, Alessandro Gori, Pierangelo Metrangolo
Affiliations

A halogen bond-donor amino acid for organocatalysis in water

Greta Bergamaschi et al. Chem Commun (Camb). .

Abstract

Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide experimental evidence that halogen bonding is a plausible explanation for the observed catalytic effect.

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