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Review
. 2019 Jan;41(1):49-58.
doi: 10.1007/s00281-018-0703-z. Epub 2018 Sep 5.

Principles of adoptive T cell therapy in cancer

Özcan Met  1   2   3 , Kasper Mølgaard Jensen  4 , Christopher Aled Chamberlain  4 , Marco Donia  4   5 , Inge Marie Svane  4   5
Affiliations
Review

Principles of adoptive T cell therapy in cancer

Özcan Met et al. Semin Immunopathol. 2019 Jan.

Abstract

Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.

Keywords: Adoptive cell therapy; Cancer immunotherapy; Chimeric antigen receptor; T cells; Tumor-infiltrating lymphocytes.

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References

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