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. 1986 Sep;83(17):6322-6.
doi: 10.1073/pnas.83.17.6322.

A DNA binding protein specific for an origin of replication of herpes simplex virus type 1

P Elias, M E O'Donnell, E S Mocarski, I R Lehman

A DNA binding protein specific for an origin of replication of herpes simplex virus type 1

P Elias et al. Proc Natl Acad Sci U S A. 1986 Sep.

Abstract

We have identified a protein that binds specifically to an origin of replication (oris) of the herpes simplex virus type 1 genome. The oris binding protein, detectable only in nuclear extracts of infected cells, shows the same time course of appearance as the herpesvirus-induced DNA polymerase and the DNA binding protein ICP8. The partially purified oris binding protein generates a DNase I "footprint" that spans 18- of the 90-base-pair minimal oris sequence. The oris binding protein may, therefore, be analogous to other origin-specific binding proteins that are required for the initiation of viral and chromosomal DNA replication.

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