Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov;35(11):1995-2002.
doi: 10.1007/s10815-018-1286-2. Epub 2018 Sep 5.

Perinatal follow-up of children born after preimplantation genetic diagnosis between 1995 and 2014

Malou Heijligers  1   2 , Aafke van Montfoort  3   4 , Madelon Meijer-Hoogeveen  5 , Frank Broekmans  5 , Katelijne Bouman  6 , Irene Homminga  7 , Jos Dreesen  8   3 , Aimee Paulussen  8   3 , John Engelen  8 , Edith Coonen  8   4 , Vyne van der Schoot  8 , Marieke van Deursen-Luijten  8 , Nienke Muntjewerff  8 , Andrea Peeters  9 , Ron van Golde  4 , Mark van der Hoeven  10 , Yvonne Arens  8 , Christine de Die-Smulders  8   3
Affiliations

Perinatal follow-up of children born after preimplantation genetic diagnosis between 1995 and 2014

Malou Heijligers et al. J Assist Reprod Genet. 2018 Nov.

Abstract

Purpose: We aim to evaluate the safety of PGD. We focus on the congenital malformation rate and additionally report on adverse perinatal outcome.

Methods: We collated data from a large group of singletons and multiples born after PGD between 1995 and 2014. Data on congenital malformation rates in live born children and terminated pregnancies, misdiagnosis rate, birth parameters, perinatal mortality, and hospital admissions were prospectively collected by questionnaires.

Results: Four hundred thirty-nine pregnancies in 381 women resulted in 364 live born children. Nine children (2.5%) had major malformations. This percentage is consistent with other PGD cohorts and comparable to the prevalence reported by the European Surveillance of Congenital Anomalies (EUROCAT). We reported one misdiagnosis resulting in a spontaneous abortion of a fetus with an unbalanced chromosome pattern. 20% of the children were born premature (< 37 weeks) and less than 15% had a low birth weight. The incidence of hospital admissions is in line with prematurity and low birth weight rate. One child from a twin, one child from a triplet, and one singleton died at 23, 32, and 37 weeks of gestation respectively.

Conclusions: We found no evidence that PGD treatment increases the risk on congenital malformations or adverse perinatal outcome.

Trial registration number: NCT 2 149485.

Keywords: Children; Congenital malformations; Follow-up; Perinatal outcome; Preimplantation genetic diagnosis.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

The authors declare that they have no competing interests.

References

    1. de Krom G, Arens YH, Coonen E, et al. Recurrent miscarriage in translocation carriers: no differences in clinical characteristics between couples who accept and couples who decline PGD. Hum Reprod. 2015;30(2):484–489. doi: 10.1093/humrep/deu314. - DOI - PubMed
    1. Harton G, Braude P, Lashwood A, et al. European Society for Human Reproduction and Embryology (ESHRE) PGD consortium. ESHRE PGD consortium best practice guidelines for organization of a PGD Centre for PGD/preimplantation genetic screening. Hum Reprod. 2011;26(1):14–24. doi: 10.1093/humrep/deq229. - DOI - PubMed
    1. Davies MJ, Moore VM, Wilson KJ, et al. Reproductive technologies and the risk of birth defects. N Engl J Med. 2012;366:19. doi: 10.1056/NEJMoa1008095. - DOI - PubMed
    1. Pandey S, Shetty A, Hamilton M, et al. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(5):485–503. doi: 10.1093/humupd/dms018. - DOI - PubMed
    1. De Rycke M, Belva F, Goossens V, et al. ESHRE PGD consortium data collection XIII: cycles from January to December 2010 with pregnancy follow-up to October 2011. Hum Reprod. 2015;30(8):1763–1789. doi: 10.1093/humrep/dev122. - DOI - PubMed

Grants and funding