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. 1986 Sep;83(18):6868-72.
doi: 10.1073/pnas.83.18.6868.

Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice

H C Morse 3rd, J W Hartley, T N Fredrickson, R A Yetter, C Majumdar, J L Cleveland, U R Rapp

Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice

H C Morse 3rd et al. Proc Natl Acad Sci U S A. 1986 Sep.

Abstract

NFS/N mice were infected within 48 hr of birth with pseudotypes of recombinant murine leukemia viruses containing avian v-myc developed T-cell, pre-B-cell, and B-cell lymphomas and epithelial tumors including pancreatic and mammary adenocarcinomas. Primary hematopoietic and epithelial tumors and continuous in vitro cell lines derived from some of these tumors, established in the absence of added growth factors, exhibited clonal integrations of v-myc and expressed v-myc RNA. These results show that deregulated expression of the myc oncogene in mammalian cells can initiate a wide variety of neoplasms.

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