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Comment
. 2018 Sep 6;12(9):e0006625.
doi: 10.1371/journal.pntd.0006625. eCollection 2018 Sep.

Recent advances in the Giardia-host relationship reveal danger lurking behind the smile

Camila H Coelho  1   2 , Steven M Singer  1
Affiliations
Comment

Recent advances in the Giardia-host relationship reveal danger lurking behind the smile

Camila H Coelho et al. PLoS Negl Trop Dis. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Interaction of Giardia and the host.
(A) Parasites release proteins, like secreted proteins and proteins contained in macrovesicles and microvesicles, such as ADI, OCT, and several proteases. (B) These secreted factors can degrade tight junction proteins and villin in the epithelial cells, degrade mucins and cytokines secreted by cells, and metabolize arginine resulting in immune evasion and immunomodulation. ADI, arginine deiminase; OCT, ornithine carbamoyltransferase.
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References

    1. Emery SJ, Mirzaei M, Vuong D, Pascovici D, Chick JM, Lacey E, et al. Induction of virulence factors in Giardia duodenalis independent of host attachment. Sci Rep. 2016;6:20765 10.1038/srep20765 . - DOI - PMC - PubMed
    1. Ankarklev J, Jerlstrom-Hultqvist J, Ringqvist E, Troell K, Svard SG. Behind the smile: cell biology and disease mechanisms of Giardia species. Nat Rev Microbiol. 2010;8(6):413–22. 10.1038/nrmicro2317 . - DOI - PubMed
    1. Certad G, Viscogliosi E, Chabe M, Caccio SM. Pathogenic Mechanisms of Cryptosporidium and Giardia. Trends Parasitol. 2017;33(7):561–76. . - PubMed
    1. Prucca CG, Lujan HD. Antigenic variation in Giardia lamblia. Cell Microbiol. 2009;11(12):1706–15. Epub 2009/08/28. 10.1111/j.1462-5822.2009.01367.x . - DOI - PubMed
    1. Ward HD, Lev BI, Kane AV, Keusch GT, Pereira ME. Identification and characterization of taglin, a mannose 6-phosphate binding, trypsin-activated lectin from Giardia lamblia. Biochemistry. 1987;26(26):8669–75. . - PubMed

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