Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Sep 14;39(35):3311-3313.
doi: 10.1093/eurheartj/ehy501.

Targeting myeloperoxidase in inflammatory atherosclerosis

Max L Senders  1   2 , Willem J M Mulder  1   2
Affiliations
Comment

Targeting myeloperoxidase in inflammatory atherosclerosis

Max L Senders et al. Eur Heart J. .
No abstract available

PubMed Disclaimer

Figures

Take home figure
Take home figure
Top: myeloperoxidase-gadolinium (MPO-Gd) facilitates identification of unstable plaques in tandem stenosis Apoe–/– mice with magnetic resonance imaging (MRI). Bottom: myeloperoxidase inhibition with AZM198 treatment results in formation of a more stable plaque phenotype with increased fibrous cap thickness, similar to the phenotype observed in tandem stenosis Apoe–/– MPO–/– double knockouts. Figures were made using Servier Medical Art (www.servier.com).
None
See this image and copyright information in PMC

Comment on

References

    1. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685–1695. - PubMed
    1. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANOS Trial Group. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 2017;377:1119–1131. - PubMed
    1. Nahrendorf M. Myeloid cell contributions to cardiovascular health and disease. Nat Med 2018;24:711–720. - PMC - PubMed
    1. Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res 2012;110:875–888. - PubMed
    1. Warnatsch A, Ioannou M, Wang Q, Papayannopoulos V.. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science 2015;349:316–320. - PMC - PubMed

Publication types