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Comment
. 2018 Sep 5;99(5):867-868.
doi: 10.1016/j.neuron.2018.08.005.

Gyrification Needs Correct Sodium Flux!

Silvia Cappello  1
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Free article
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Gyrification Needs Correct Sodium Flux!

Silvia Cappello. Neuron. .
Free article

Abstract

Channelopathies are disorders that affect the function of ion channels, typically resulting in epilepsy. Smith et al. (2018) discover an unusual association between SCN3A, neuronal migration, and cortical folding, outlining sodium channels as important regulators of brain development.

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  • Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development.
    Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, Salonen O, Barkovich AJ, Poduri A, Wilke M, de Wit MCY, Mancini GMS, Sztriha L, Im K, Amrom D, Andermann E, Paetau R, Lehesjoki AE, Walsh CA, Lehtinen MK. Smith RS, et al. Neuron. 2018 Sep 5;99(5):905-913.e7. doi: 10.1016/j.neuron.2018.07.052. Epub 2018 Aug 23. Neuron. 2018. PMID: 30146301 Free PMC article.