Review
doi: 10.1126/science.3018928.
Early signals in the mitogenic response
- PMID: 3018928
- DOI: 10.1126/science.3018928
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Review
Early signals in the mitogenic response
Science.
.
Abstract
Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.
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