Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep 5;7(9):119.
doi: 10.3390/antiox7090119.

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

Takuji Kawamura  1 , Isao Muraoka  2
Affiliations
Review

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

Takuji Kawamura et al. Antioxidants (Basel). .

Abstract

It is well established that the increase in reactive oxygen species (ROS) and free radicals production during exercise has both positive and negative physiological effects. Among them, the present review focuses on oxidative stress caused by acute exercise, mainly on evidence in healthy individuals. This review also summarizes findings on the determinants of exercise-induced oxidative stress and sources of free radical production. Moreover, we outline the effects of antioxidant supplementation on exercise-induced oxidative stress, which have been studied extensively. Finally, the following review briefly summarizes future tasks in the field of redox biology of exercise. In principle, this review covers findings for the whole body, and describes human trials and animal experiments separately.

Keywords: animal experiments; antioxidants; exercise performance; exercise-induced oxidative stress; free radicals; human trials; muscle damage; reactive oxygen species.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Redox balance and oxidative stress in living organisms.
Figure 2
Figure 2
Determinants of exercise-induced oxidative stress and sources of free radical production. NADPH: nicotinamide adenine dinucleotide phosphate.
Figure 3
Figure 3
Reactive species and physiological adaptations to endurance training.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology & Medicine. 5th ed. Oxford University Press; New York, NY, USA: 2007.
    1. Commoner B., Townsend J., Pake G.E. Free Radicals in Biological Materials. Nature. 1954;174:689–691. doi: 10.1038/174689a0. - DOI - PubMed
    1. Mallard J.R., Kent M. Electron Spin Resonance in Surviving Rat Tissues. Nature. 1966;210:588–591. doi: 10.1038/210588a0. - DOI - PubMed
    1. Wyard S.J. Electron Spin Resonance Spectroscopy of Animal Tissues. Proc. Roy. Soc. A. 1968;302:355–360. doi: 10.1098/rspa.1968.0021. - DOI
    1. Morrow J.D., Awad J.A., Kato T., Takahashi K., Badr K.F., Roberts L.J., 2nd, Burk R.F. Formation of Novel Non-cyclooxygenase-Derived Prostanoids (F2-Isoprostanes) in Carbon Tetrachloride Hepatotoxicity. An Animal Model of Lipid Peroxidation. J. Clin. Investig. 1992;90:2502–2507. doi: 10.1172/JCI116143. - DOI - PMC - PubMed

LinkOut - more resources