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. 2018 Sep 3;8(9):88.
doi: 10.1038/s41408-018-0122-3.

Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib

Oliver Ottmann  1 , Giuseppe Saglio  2 , Jane F Apperley  3 , Christopher Arthur  4 , Eduardo Bullorsky  5 , Aude Charbonnier  6 , John F Dipersio  7 , Hagop Kantarjian  8 , Hanna Jean Khoury  9 , Dong-Wook Kim  10 , Diane Healey  11 , Lewis Strauss  11 , Jorge E Cortes  8
Affiliations

Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib

Oliver Ottmann et al. Blood Cancer J. .
No abstract available

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Conflict of interest statement

O.O. has acted as a consultant, advisor, or speaker for ARIAD, Bristol-Myers Squibb, Celgene, Fusion Pharma, Novartis, Pfizer, Roche, and SUN Pharma. G.S. has acted as a consultant and a speaker for ARIAD, Bristol-Myers Squibb, Novartis, and Pfizer. J.F.A. is an NIHR Senior Investigator and acknowledges the support of the Imperial College NIHR Biomedical Research Centre and has acted as a consultant, speaker, and advisor for ARIAD, Bristol-Myers Squibb, Incyte, Novartis, Pfizer, and SUN Pharma. C.A. has served on advisory boards and acted as a speaker for ARIAD, Bristol-Myers Squibb, Novartis, and Pfizer. E.B. has no disclosures to declare. A.C. has served on advisory boards and has acted as a speaker for Bristol-Myers Squibb, Incyte, Novartis, and Pfizer. J.F.D. has no disclosures to declare. H.K. has served on advisory boards for ARIAD, Bristol-Myers Squibb, Novartis, and Pfizer. H.J.K. has no disclosures to declare. D.-W.K. has received research funding from and served on an advisory committee for Bristol-Myers Squibb. D.H. and L.S. are employees of Bristol-Myers Squibb. J.C. has served as a consultant to and received research funding from ARIAD, Bristol-Myers Squibb, Novartis, Pfizer, and Teva.

Figures

Fig. 1
Fig. 1. Efficacy outcomes for patients with CML-AP by dosing schedule.
a Duration of MaHR for patients who achieved MaHR, b PFS, and c OS are shown for the QD (solid lines) and BID (dashed lines) dosing groups. Efficacy analyses were conducted in the intention-to-treat population of patients. BID twice a day, CI confidence interval, MaHR major hematologic response, NA not available, OS overall survival, PFS progression-free survival, QD once a day
See this image and copyright information in PMC

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