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. 2018 Sep 1:9:106-116.
doi: 10.1515/tnsci-2018-0017. eCollection 2018.

Evaluation of Two Types of Drug Treatment with QEEG in Children with ADHD

Ramazan Aldemir  1 , Esra Demirci  2 , Ayşe Kaçar Bayram  3 , Mehmet Canpolat  3 , Sevgi Ozmen  2 , Hüseyin Per  3 , Mahmut Tokmakci  4
Affiliations

Evaluation of Two Types of Drug Treatment with QEEG in Children with ADHD

Ramazan Aldemir et al. Transl Neurosci. .

Abstract

Aims: The aim of this study is to evalute the effects of methylphenidate and atomoxetine treatments on electroencephalography (EEG) signals in volunteer children diagnosed with Attention Deficit and Hyperactivity Disorder(ADHD).

Methods: The study contained 40 children all of whom were between the ages of 7 and 17. The participants were classified into two groups as ADHD (n=20), which was in itself divided into two groups as ADHD-MPH (ADHD- Metylphenidate treatment) (n=10) and as ADHD-ATX (ADHD-Atomoxetin treatment) (n=10), and one control group (n=20). Following the first EEG recordings of the ADHD group, long-acting methylphenidate dose was applied to one ADHD group and atomoxetine dose was applied to the other ADHD group. The effect of optimal dosage is about for 4-6 weeks in general. Therefore, the response or lack of response to the treatment was evaluated three months after the beginning of the treatment.After methylphenidate and atomoxetine drug treatment, in order to obtain mean and maximum power values for delta, theta, alpha and beta band, the EEG data were analyzed.

Results: The EEG power spectrum densities in all the bands yielded similar findings in both methylphenidate and atomoxetine. Although statistically significant frequency values of the electrodes were amplitude and maximally varied, in general, they appeared mostly at both frontal and temporal regions for methylphenidate and atomoxetine.

Conclusion: Especially, after atomoxetine treatment, Quantitative Electroencephalography (QEEG) rates at frontal area electrodes were found statistically more significant than methylphenidate QEEG rates. What has been researched in this study is not only whether QEEG is likely to support the diagnosis, but whether changes on QEEG by treatment may be related to the severity of ADHD as well.

Keywords: Attention-deficit hyperactivity disorder (ADHD); QEEG; drug treatment; non-stimulants; stimulants.

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Figures

Figure 1
Figure 1
EEG signal processing and statistical analysis stages.
Figure 2
Figure 2
Mean power change in EEG bands between Methylphenidate using ADHD and Control groups. (a)Delta band, (b)Theta band, (c)Alpha band, and (d)Beta band
Figure 3
Figure 3
Mean power change in EEG bands between Atomoxetine using ADHD and Control groups. (a)Delta band, (b)Theta band, (c)Alpha band, and (d)Beta band
Figure 4
Figure 4
Representation of the statistically significant active electrodes according to the maximum frequency, maximum amplitude, and mean amplitude of power values (a) for the Methylphenidate using ADHD/Control groups, and (b) for the Atomoxetine using ADHD/Control groups.
Figure 5
Figure 5
Statistical comparison of QEEG ratios after (a) Methylphenidate using ADHD and (b) Atomoxetine using ADHD
See this image and copyright information in PMC

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