[INVOLVEMENT OF NITRIC OXIDE CYNTHASE IN THE EARLY PHASE OF THE HEART ISCHEMIC PRECONDITIONING]

Abstract

Currently there is no single answer on the question of the participation of nitric oxide and NO-synthase (NOS) in the cardioprotection in the early phase of ischemic preconditioning (IP). In the present review the results of experimental studies indicate the involvement of NOS in the protective effect of IP and the literature data refuting this assumption. In addition, it was presented data on the increase of nitrates and nitrites (the stable metabolite of NO) in myocardial tissue after the IP, an increase in the expression of genes encoding NOS immediately after the IP, the data on the elimination of the protective effect of IP of NOS blockers and of imitation of IP affects IP by nitric oxide donors. It was exhibited a brief analysis of some of the studied mechanisms involving NO and NOS in cardioprotection at IP.