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Comment
. 2018 Sep 6;71(5):649-651.
doi: 10.1016/j.molcel.2018.08.032.

Pour Some Sugar on TDP(-43)

Steven Boeynaems  1 , Aaron D Gitler  2
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Free article
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Pour Some Sugar on TDP(-43)

Steven Boeynaems et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, McGurk et al. (2018) identify how poly(ADP-ribose) binding tunes the phase behavior of the ALS disease protein TDP-43, uncovering the molecular events underlying its aggregation in disease and illuminating a novel therapeutic target.

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