Set Phasers to Cleave: PIWI Cleavage Directs All piRNA Biogenesis

Affiliations

¹ Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mourelaz@uphs.upenn.edu.

Comment

Anastassios Vourekas et al. Mol Cell. 2018.

. 2018 Sep 6;71(5):651-652.

doi: 10.1016/j.molcel.2018.08.035.

¹ Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mourelaz@uphs.upenn.edu.

Abstract

In this issue of Molecular Cell, Gainetdinov et al. (2018) show that PIWI proteins direct both piRNA biogenesis and piRNA function in most animals.

A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals.
Gainetdinov I, Colpan C, Arif A, Cecchini K, Zamore PD. Gainetdinov I, et al. Mol Cell. 2018 Sep 6;71(5):775-790.e5. doi: 10.1016/j.molcel.2018.08.007. Mol Cell. 2018. PMID: 30193099 Free PMC article.