Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Sep 6;174(6):1339-1341.
doi: 10.1016/j.cell.2018.08.035.

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

Haiyang Yu  1 , Don W Cleveland  2
Affiliations
Free article
Comment

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

Haiyang Yu et al. Cell. .
Free article

Abstract

Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources