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Comment
. 2018 Sep 6;174(6):1344-1346.
doi: 10.1016/j.cell.2018.08.023.

Metabolic Frugality Marks Cancer Cells for Immune Targeting

Lucas B Sullivan  1
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Free article
Comment

Metabolic Frugality Marks Cancer Cells for Immune Targeting

Lucas B Sullivan. Cell. .
Free article

Abstract

Altered cell metabolism is ubiquitous in cancer cells; however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer cells for recognition by immunotherapy.

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  • Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
    Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, Auslander N, Keshet R, Stettner N, Silberman A, Agemy L, Helbling D, Eilam R, Sun Q, Brandis A, Malitsky S, Itkin M, Weiss H, Pinto S, Kalaora S, Levy R, Barnea E, Admon A, Dimmock D, Stern-Ginossar N, Scherz A, Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A. Lee JS, et al. Cell. 2018 Sep 6;174(6):1559-1570.e22. doi: 10.1016/j.cell.2018.07.019. Epub 2018 Aug 9. Cell. 2018. PMID: 30100185 Free PMC article.

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