Nucleotide and derived amino acid sequences of a cDNA coding for pre-uteroglobin from the lung of the hare (Lepus capensis)
- PMID: 3019311
- PMCID: PMC1146772
- DOI: 10.1042/bj2350895
Nucleotide and derived amino acid sequences of a cDNA coding for pre-uteroglobin from the lung of the hare (Lepus capensis)
Abstract
An almost full-length cDNA coding for pre-uteroglobin from hare lung was cloned and sequenced. The derived amino acid sequence indicated that hare pre-uteroglobin contained 91 amino acids, including a signal peptide of 21 residues. Comparison of the nucleotide sequence of hare pre-uteroglobin cDNA with that previously reported for the rabbit gene indicated five silent point substitutions and six others leading to amino acid changes in the coding region. The untranslated regions of both pre-uteroglobin mRNAs were very similar. The amino acid changes observed are discussed in relation to the different progesterone-binding abilities of both homologous proteins.
Similar articles
-
Uteroglobin mRNA from the lung of the hare (Lepus capensis): cell-free translation and properties.Comp Biochem Physiol B. 1984;78(4):885-90. doi: 10.1016/0305-0491(84)90204-9. Comp Biochem Physiol B. 1984. PMID: 6205820
-
Hormonally regulated mammalian gene expression: steady-state level and nucleotide sequence of rabbit uteroglobin mRNA.DNA. 1981;1(1):19-26. doi: 10.1089/dna.1.1981.1.19. DNA. 1981. PMID: 6299663
-
Isolation and characterization of uteroglobin from the lung of the hare (Lepus capensis).Arch Biochem Biophys. 1983 Oct 15;226(2):539-47. doi: 10.1016/0003-9861(83)90323-5. Arch Biochem Biophys. 1983. PMID: 6639070
-
Uteroglobin: a model for the sutyd of progesterone action in mammals.DNA. 1983;2(2):99-104. doi: 10.1089/dna.1983.2.99. DNA. 1983. PMID: 6307625 Review.
-
The uteroglobin gene, structure and interaction with the progesterone-receptor.Oxf Surv Eukaryot Genes. 1984;1:192-214. Oxf Surv Eukaryot Genes. 1984. PMID: 6400774 Review. No abstract available.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous