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Comment
. 2018 Sep 6;23(3):315-317.
doi: 10.1016/j.stem.2018.08.003.

Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells

Fabrizio Simeoni  1 , Tim C P Somervaille  2
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Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells

Fabrizio Simeoni et al. Cell Stem Cell. .
Free article

Abstract

Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.

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