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. 2018 Sep 7;17(1):209.
doi: 10.1186/s12944-018-0863-9.

Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China

Yan Wang  1 , Jun Zhang  2 , Yanrong Ma  3 , Xiangxin Song  3 , Suli Li  3 , Xianqin Zhan  4 , Lan Wu  3
Affiliations

Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China

Yan Wang et al. Lipids Health Dis. .

Abstract

Background: This study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance.

Methods: Participants' data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson's correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics.

Results: HOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0.001). The Matsuda Index of Kazaks was significantly higher than that of Hans and Uygurs (P < 0.001). While Kazaks had the highest BMI, WC, SBP, and DBP; they also had the highest HDL-C and lowest TG (P < 0.001). TG of Uygurs was significantly higher than that of Hans and Kazaks (P < 0.001). In Hans and Kazaks, the TG/HDL-C ratio increased with HOMA-IR quartiles; there was no association in Uygurs. In Hans and Kazaks, the TG/HDL-C ratio decreased with Matsuda index quartiles; there was no association in Uygurs. Multivariate linear regression showed that HOMA-IR was independently associated with ethnicity, BMI and TG/HDL-C ratio (P < 0.01), while Matsuda index was independently associated with ethnicity, BMI, LDL-C levels (P < 0.001) and TG/HDL-C ratio (P < 0.001).

Conclusions: In conclusion, Han, Uygur, and Kazak men had different lipid profiles, BMI, and WC. Han men had the highest insulin resistance while Kazak men had the highest insulin sensitivity.

Keywords: Epidemiology; Ethnic differences; Glucose metabolism; Han; Insulin resistance; Insulin sensitivity; Kazak; Lipid metabolism; Uygur.

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Conflict of interest statement

Ethics approval and consent to participate

The present study was approved by the ethics committee each participating institutions in the Xinjiang province. Written informed consent was obtained for the main study and for eventual substudies The need for individual consent for this subset study was waived by the committee.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
a TG/HDL-C ratio according to HOMA-IR among Han, Uygur, and Kazak men. b TG/HDL-C ratio according to the Matsuda index among Han, Uygur, and Kazak men. TG/HDL-C ratio denoted by different letters indicated significant difference between quartiles
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