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Review
. 2018 Sep 7;293(36):14190-14191.
doi: 10.1074/jbc.H118.005121.

Walking a fine line between β-cell secretion and proliferation

Adrian Vella  1 , Aleksey Matveyenko  2   3
Affiliations
Review

Walking a fine line between β-cell secretion and proliferation

Adrian Vella et al. J Biol Chem. .

Abstract

Of the many common genetic variants associated with type 2 diabetes, that in TCF7L2 remains the most studied because it has the greatest effect size. However, the mechanism by which this variant alters diabetes risk remains elusive. A new study adds another layer of complexity, suggesting that the effects of TCF7L2 are context-dependent, and highlights a novel interaction that might bias a β-cell to a secretory or proliferative phenotype. This in turn might open up new avenues to the restoration of insulin secretion in people with type 2 diabetes.

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Conflict of interest statement

The authors declare that they have no conflicts of interest with the contents of this article

Figures

Figure 1.
Figure 1.
A proposed model for the interaction of TCF7L2 with LKB1 and mTOR in regulating β-cell proliferation and secretion.
See this image and copyright information in PMC

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