Overview of Serpins and Their Roles in Biological Systems

Abstract

Serine protease inhibitors are ubiquitous regulators for a multitude of pathways in humans. The serpins represent an ancient pathway now known to be present in all kingdoms and often regulating central pathways for clotting, immunity, and even cancer in man. Serpins have been present from the time of the dinosaurs and can represent a large proportion of circulating blood proteins. With this introductory chapter, we present an overview of serpins as well as an introduction and overview of the chapters describing the methodology used in the new approaches to understanding their molecular mechanisms of action and their roles in health and disease.

Keywords: Bacteria; Crystallography; Inflammation; Kinetics; Malaria; Microbiome; Neurotrauma; Peptides; Phage; Serpin; Serpinopathy; Thrombosis; Trypsin; Virus.