Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Aug;5(8):1857-63.
doi: 10.1002/j.1460-2075.1986.tb04437.x.

Molecular characterisation of a hypervariable region downstream of the human alpha-globin gene cluster

A P Jarman, R D Nicholls, D J Weatherall, J B Clegg, D R Higgs

Molecular characterisation of a hypervariable region downstream of the human alpha-globin gene cluster

A P Jarman et al. EMBO J. 1986 Aug.

Abstract

We have characterised an unusual, highly polymorphic region of DNA located 8-kb downstream of the human alpha-globin gene complex. This hypervariable region (alpha-globin 3' HVR) is composed of an array of 17-bp tandem repeats, the number of which differs considerably (70-450) from one allele to another. The sequence of the 17-bp repeats is highly conserved within and between alleles. Furthermore, this sequence identifies a core oligonucleotide [5'-GNGGGG(N)ACAG-3'] that is common to three previously characterised hypervariable regions. At reduced stringency, a probe to the 3' HVR detects a new family of multiallelic loci that will be of value in the study of human genetics.

PubMed Disclaimer

References

    1. Nature. 1970 Aug 22;227(5260):794-8 - PubMed
    1. Mol Cell Biol. 1985 Oct;5(10):2533-42 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Science. 1976 Feb 13;191(4227):528-35 - PubMed
    1. Nucleic Acids Res. 1976 Sep;3(9):2387-98 - PubMed

Publication types